What are clinical trials and why do people participate? Clinical trials are part of clinical research and at the heart of all medical advances. Clinical trials look at new ways to prevent, detect, or treat disease. Studies might involve new investigational drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments.
Placebos can cause terrible side effects. Aside from the sort of side effects that you expect with any drug, there are three side effects of SSRIs that I consider especially worrisome and worthy of further discussion. These are weight gain, sexual side effects, and emotional blunting. Weight gain is often listed as one of the most common and debilitating effects of SSRIs.
But amusingly, when a placebo-controlled double-blinded study was finally run, SSRIs produced less weight gain than placebo. After a year of pill-taking, people on Prozac had gained 3. There is now some talk of SSRIs as a weak but statistically significant agent for weight loss.
One symptom of depression is not eating. Then they get better, either because the drugs worked, because of placebo, or just out of regression to the mean. When you go from not eating to eating, you gain weight.
Sexual side effects are a less sanguine story. Here the direction was opposite: Numbers I have heard for the percent of people on SSRIs with sexual side effects include 14, 24, 37, 58, 59, and 70 several of those come from here.
Researchers investigating the topic suggest people worried about sexual side effects should switch to alternative sexual-side-effect-free antidepressant Serzone. You may remember that as the antidepressant that worked worst in the efficacy studies and brought the efficacy of all the other ones down with it.
Also, it causes liver damage. In my opinion, a better choice would be bupropion, another antidepressant which has been found many times not to cause sexual side effects and which may even improve your sex life.
Bupropion causes insomnia, decreased appetite, and in certain rare cases of populations at risk, seizures.
It is generally a good choice for people who are worried about SSRI side effects and would prefer a totally different set of side effects. So after you recover, you can wait the appropriate amount of time, come off the drugs or switch to a different drug or dose for maintenance and no harm done.
The situation no longer seems so innocuous. Despite a lack of systematic investigation, there are multiple reports from researchers and clinicians — not to mention random people on the Internet — of permanent SSRI-induced sexual dysfunction that does not remit once the drug is stopped.
This is definitely not the norm and as far as we know it is so rare as to be unstudyable beyond the occasional case report. On the other hand, I have this. But I am very suspicious. I feel like this provides moderate anthropic evidence that it is not as rare as everyone thinks.
The last side effect worth looking at is emotional blunting.The claim that “SSRIs don’t work” or “SSRIs are mostly just placebo” is most commonly associated with Irving Kirsch, a man with the awesome job title of “Associate Director Of The Program For Placebo Studies at Harvard”.
This post is in response to a comment on the Why Do Married Men Masturbate post where a wife’s husband admitted to masturbating and she’s struggling with how to deal with that revelation.
I’ve copied the comment below for reference. Thank you for this mtb15.com reading it, something told me I needed to discuss it with my husband.
Health news with a focus on fitness news, wellness coverage and living a healthy Southern California life. Patellofemoral pain syndrome (PFPS), also known as runner’s knee, is the most common of all kinds of knee pain, causing pain around and under the mtb15.com anyone can get it, but it particularly affects runners, cyclists and hikers, and also office workers or anyone else who sits for .
GABA supplements are promoted by many as a safe and natural way to reduce anxiety levels and help combat stress. This chemical occurs naturally in your brain and produces feelings of calm, lessens the neurological signs of nervousness and stress, increases focus, and aids in falling and staying alseep.
Question: What Is A Placebo And Why Might It Be Used In The Treatment Of Pain? Answer: Many patients with pain know that placebos are used when drugs are .